Pharm DiG 2. More.

Digoxin (lanoxin Uses):

Primary use: Treats systolic heart failure and atrial fibrillation.
Latest Heart Failure Treatment Guideline recommends: Digoxin (lanoxin) is used as an adjunct to drugs of other classes, including beta blockers, diuretics, Ace inhibitors’ and ARBs in selected Patients.

Contraindication

This is when you don’t use.

  • Allergy and may include second – or third-degree heart block.
  • Ventricular fibrillation, and heart failure resulting from diastolic dysfunction.

Adverse Effects: Undesirable effects:

  • Cardiovascular: Bradycardia (slow heart rate) or Tachycardia (fast heart rate), hypotension.
  • Central Nervous system: Headache, Fatigue, confusion, convulsions.
  • Eye: Colored vision: green, yellow, or purple), halo vision.
  • GI: Anorexia, Nausea, Vomiting, Diarrhea.

Points:

  • Digoxin has a low therapeutic range: 0.5 to 2 ng/ml
  • Closely monitor Digoxin for toxicity even after reaching steady state
  • Decrease in renal function is a common cause of digoxin toxicity
  • Digoxin is excreted almost exclusively through the kidney
If Toxicity occurs:

Digoxin immune Fab: Digoxin antidote:
Digoxin immune Fab therapy is indicated only for the following:

  • Hyperkalemia (serum potassium level higher than 5 mEq/L) in a patient with digoxin toxicity.
  • Life-Threatening cardiac dysrhythmias, sustained ventricular tachycardia or fibrillation, and severe sinus bradycardia or heart block unresponsive to atropine treatment or cardia pacing.
  • Life threatening overdose: more than 10 mg digoxin in adults, more than 4 mg in children.

 

DiG Pharm 2. TexT Book: SOURCE : Pharmacology and the Nursing Process: EIGHT EDITION. 

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