Digoxin (lanoxin Uses):
Primary use: Treats systolic heart failure and atrial fibrillation.
Latest Heart Failure Treatment Guideline recommends: Digoxin (lanoxin) is used as an adjunct to drugs of other classes, including beta blockers, diuretics, Ace inhibitors’ and ARBs in selected Patients.
This is when you don’t use.
- Allergy and may include second – or third-degree heart block.
- Ventricular fibrillation, and heart failure resulting from diastolic dysfunction.
Adverse Effects: Undesirable effects:
- Cardiovascular: Bradycardia (slow heart rate) or Tachycardia (fast heart rate), hypotension.
- Central Nervous system: Headache, Fatigue, confusion, convulsions.
- Eye: Colored vision: green, yellow, or purple), halo vision.
- GI: Anorexia, Nausea, Vomiting, Diarrhea.
- Digoxin has a low therapeutic range: 0.5 to 2 ng/ml
- Closely monitor Digoxin for toxicity even after reaching steady state
- Decrease in renal function is a common cause of digoxin toxicity
- Digoxin is excreted almost exclusively through the kidney
If Toxicity occurs:
Digoxin immune Fab: Digoxin antidote:
Digoxin immune Fab therapy is indicated only for the following:
- Hyperkalemia (serum potassium level higher than 5 mEq/L) in a patient with digoxin toxicity.
- Life-Threatening cardiac dysrhythmias, sustained ventricular tachycardia or fibrillation, and severe sinus bradycardia or heart block unresponsive to atropine treatment or cardia pacing.
- Life threatening overdose: more than 10 mg digoxin in adults, more than 4 mg in children.
DiG Pharm 2. TexT Book: SOURCE : Pharmacology and the Nursing Process: EIGHT EDITION.